Projects
Computational protein design projects and research initiatives
Factor X Engineering
2021-2025Goal: Rationally engineer catalytically active serine protease coagulation Factor X variants with reduced binding of small-molecule and natural inhibitors for therapeutic purposes.
Key Achievements:
- • Developed computational pipeline for assessing enzymatic competence of engineered variants
- • Identified interaction hotspots for inhibitor-resistant design
- • Guided experimental validation of computationally designed variants
- • Manuscript under revision at Journal of Chemical Information and Modeling
Protein Abundance Prediction
2025Roche PMDA Summer School 2025: Developed predictive models for protein abundance in mouse kidney tissue using curated multi-species datasets.
Approach:
- • Performed exploratory data analysis revealing strong correlations between orthologs
- • Trained multiple ML models (XGBoost, Neural Networks, Random Forest)
- • Investigated sequence-based embeddings for improved predictions
- • Outperformed baseline linear regression models
Protein-Oligosaccharide Modeling
2021Master's Thesis: Current modelling approaches to generate 3D structures of protein-oligosaccharide complexes.
Investigated computational methods for modeling complex carbohydrate-protein interactions, which are crucial for understanding biological recognition processes and designing therapeutics.
Factor Xa Variant Engineering
2019-2021Minor Internship: Engineering Factor Xa variants with lower Apixaban binding affinity.
Early work in computational protein design, focusing on understanding and modifying protein-drug interactions through molecular modeling and free energy calculations.
Collaborative Research
Throughout my research, I have maintained active collaborations with experimental groups at Vrije Universiteit Amsterdam and the University of Basel, bridging computational predictions with experimental validation.
My work has contributed to multiple peer-reviewed publications and has been presented at international conferences, including the International Society on Thrombosis & Haemostasis and the European Congress of Thrombosis and Haemostasis.